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GRN 3′UTR+78 C>T is not associated with risk for Parkinson’s disease
Author(s) -
JasinskaMyga B.,
Wider C.,
Opala G.,
KrygowskaWajs A.,
Barcikowska M.,
Czyzewski K.,
Baker M.,
Rademakers R.,
Uitti R. J.,
Farrer M. J.,
Ross O. A.,
Wszolek Z. K.
Publication year - 2009
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2009.02621.x
Subject(s) - frontotemporal lobar degeneration , parkinsonism , medicine , disease , parkinson's disease , untranslated region , single nucleotide polymorphism , three prime untranslated region , oncology , frontotemporal dementia , lrrk2 , genetics , genotype , gene , messenger rna , biology , dementia
Background and purpose: A single nucleotide polymorphism in the 3′‐untranslated region of the progranulin gene ( GRN ; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin‐positive inclusions (FTLD‐U). rs5848 is located within a micro‐RNA binding site and affects the expression of GRN . Methods: As FTLD‐U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson’s disease in two Caucasian patient–control series ( n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson’s disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson’s disease in the US and Polish populations.