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Changes in cerebral blood flow after acetazolamide: an experimental study comparing near‐infrared spectroscopy and SPECT
Author(s) -
Schytz H. W.,
Wienecke T.,
Jensen L. T.,
Selb J.,
Boas D. A.,
Ashina M.
Publication year - 2009
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02398.x
Subject(s) - acetazolamide , cerebral blood flow , medicine , nuclear medicine , indocyanine green , blood flow , bolus (digestion) , single photon emission computed tomography , anesthesia , surgery
Background and purpose: It is important to find a reliable and bedside method, which can estimate the cerebral blood flow (CBF) of patients in clinical settings. Estimation of CBF by calculating a blood flow index (BFI) using continuous wave near‐infrared spectroscopy (CW‐NIRS) and indocyanine green (ICG) as an iv tracer has been proposed to be a feasible and promising method. To validate if the BFI method can detect relative changes in CBF we compared data with the established method 133 Xenon single photon emission computer tomography ( 133 Xe‐SPECT). Methods: Ten healthy subjects were investigated before and after a bolus of acetazolamide. NIRS data were obtained using a multi source detector separation configuration in order to assess a corrected BFI (BFI corr ) value, which attempts to eliminate contamination of skin blood flow. Results: Data obtained showed no significant correlation between CBF changes measured by 133 Xe‐SPECT and BFI corr (0.133, P = 0.732). After acetazolamide, a 49% increase in CBF was detected using the 133 Xe‐SPECT method, whereas no changes in any ICG variables were observed after acetazolamide. Conclusion: The study shows that it is not possible to obtain reliable BFI data, which reflect changes in CBF after acetazolamide infusion, using the CW‐NIRS and ICG method.