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The beneficial effect of statins treatment by stroke subtype
Author(s) -
MartínezSánchez P.,
RiveraOrdóñez C.,
Fuentes B.,
OrtegaCasarrubios M. A.,
Idrovo L.,
DíezTejedor E.
Publication year - 2009
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02370.x
Subject(s) - medicine , stroke (engine) , etiology , modified rankin scale , observational study , logistic regression , lacunar stroke , cerebral infarction , risk factor , cardiology , physical therapy , ischemic stroke , ischemia , mechanical engineering , engineering
Background and purpose: Statins have shown some protective effect after ischaemic stroke in observational studies. However, this effect has never been assessed by etiological subtypes. Methods: Observational study using data from the Stroke Unit Data Bank from consecutive patients with cerebral infarction. Variables analyzed: demographic data, cardiovascular risk factors, treatment with statins at stroke onset, stroke severity, stroke subtype, in‐hospital complications, length of stay, and functional status at discharge (modified Rankin Scale). Results: A total of 2742 patients were included, 1539 were men. Mean age was 69.17 years (SD 12.19). Of these, 281 patients (10.2%) were receiving statins when admitted. The logistic regression analyses showed that previous treatment with statins was an independent predictor for better outcome at discharge among all strokes (OR, 2.08; 95% CI, 1.39 to 3.1) as well as for the atherothrombotic (OR, 2.79; 95% CI, 1.33 to 5.84) and lacunar strokes (OR, 2.28; 95% CI, 1.15 to 4.52) after adjustment for demographic data, risk factors, previous treatments, stroke subtypes, stroke severity, in‐hospital complications and length of stay. This benefit was not observed either in cardioembolic or in other etiology strokes. Conclusions: Previous treatment with statins is an independent factor associated with good outcomes in patients with ischaemic stroke. Atherothrombotic and small vessel strokes show the greatest benefit.