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The coding‐synonymous polymorphism rs1045280 (Ser280Ser) in β‐arrestin 2 ( ARRB2 ) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia
Author(s) -
Liou Y.J.,
Wang Y.C.,
Chen J.Y.,
Chen M.L.,
Chen T.T.,
Bai Y.M.,
Lin C.C.,
Liao D.L.,
Lai I.C.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02316.x
Subject(s) - tardive dyskinesia , antipsychotic , medicine , allele , dyskinesia , risperidone , single nucleotide polymorphism , typical antipsychotic , dopamine receptor d2 , genotype , schizophrenia (object oriented programming) , dopamine , pharmacology , psychiatry , gene , genetics , parkinson's disease , atypical antipsychotic , disease , biology
Background: Tardive dyskinesia (TD) is a severe and potentially irreversible adverse effect of long‐term antipsychotic treatment. Typical antipsychotics are commonly binding to the dopamine receptor D2 (DRD2), but the occurrence of antipsychotic‐induced TD is rather delayed; therefore, the development of TD may be associated with mediators or signalling complexes behind DRD2, such as β‐arrestin 2 (ARRB2), an important mediator between DRD2 and serine–threonine protein kinase (AKT) signal cascade. Methods: A case–control study to evaluate the association between rs1045280 (Ser280Ser) and antipsychotic‐induced TD was performed amongst 381 patients (TD/non‐TD = 228/153). Results: There was a significant difference in the genotype distribution between TD and non‐TD groups ( P = 0.025); furthermore, the allelic analysis indicated that patients with T allele had increased risk of TD occurrence (OR T = 1.58, 95% CI = 1.14–2.19, P = 0.007). Conclusions: To the best of our knowledge, this is the first study reporting a positive association between the SNP rs1045280 and TD in schizophrenic patients.