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Case–control study of patients with essential tremor in Latvia
Author(s) -
Inashkina I.,
Radovica I.,
Smeltere L.,
Vitols E.,
Jankevics E.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02225.x
Subject(s) - medicine , essential tremor , clinical neurology , physical medicine and rehabilitation , neuroscience , biology
Background: Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known. Methods: We genotyped 16 microsatellite markers in a case–control cohort consisting of 104 patients and 116 controls. Results: No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02–1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls. Conclusion: There was not a significant difference in genotypic distribution between disease group and control subjects ( χ 2 = 2.8, P = 0.25).