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No evidence of association between frontotemporal dementia and major European mtDNA haplogroups
Author(s) -
Rose G.,
Longo T.,
Maletta R.,
Passarino G.,
Bruni A. C.,
De Benedictis G.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02222.x
Subject(s) - haplogroup , human mitochondrial dna haplogroup , frontotemporal dementia , mitochondrial dna , medicine , haplotype , disease , subclade , genetics , dementia , allele , biology , pathology , gene , clade , phylogenetics
Background and purpose: Mitochondrial DNA (mtDNA) inherited variability (haplogroup/sub‐haplogroup) is currently emerging as not being neutral with respect to several complex traits like neurodegenerative diseases. Here we investigated the association of European mtDNA haplogroups/sub‐haplogroups with frontotemporal dementia (FTD). Method and Results: A case‐control study was carried out on 114 patients with FTD (68 sporadic and 46 familial) and 180 controls, matched for age, gender and ethnicity. No association was found. Conclusions: European mtDNA haplogroups/sub‐haplogroups are unlikely to play a major role in the risk of developing the disease.