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Immunophenotyping in Tourette syndrome – a pilot study
Author(s) -
Möller J. C.,
Tackenberg B.,
HeinzelGutenbrunner M.,
Burmester R.,
Oertel W. H.,
Bandmann O.,
MüllerVahl K. R.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02159.x
Subject(s) - tourette syndrome , medicine , bonferroni correction , pathogenesis , immune system , cd69 , lymphocyte , immunophenotyping , immunology , flow cytometry , t cell , psychiatry , statistics , mathematics , il 2 receptor
Background and purpose: The cause of Tourette syndrome (TS) is not precisely known, although several lines of evidence point at an involvement of the immune system in its pathogenesis. Results: Here, we report the results of a pilot study investigating frequently analysed lymphocyte surface markers in 20 adult patients with TS (16 males; 37.3 ± 15.8 years) and 20 matched controls (16 males; 37.5 ± 15.3 years). Statistical analysis revealed significant differences for the investigated lymphocyte surface markers. The difference in CD69 + /CD22 + ‐B cells (23.0 ± 10.5% vs. 13.1 ± 6.1%; P = 0.001) and in CD95 + /CD4 + ‐T cells (41.5 ± 12.1% vs. 24.6 ± 10.0%; P = 0.0001) was still significant after Bonferroni–Holm correction. Conclusion: Our preliminary data indicate that TS may be associated with an increased peripheral immune activity.