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Cytotoxic T lymphocyte associated antigen‐4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis
Author(s) -
Haghighi A. Borhani,
Ghahramani S.,
Azarpira N.,
Pourjafar M.,
Nikseresht A. R.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02153.x
Subject(s) - cytotoxic t cell , medicine , genotype , odds ratio , confidence interval , multiple sclerosis , exon , immunology , allele , antigen , lymphocyte , gastroenterology , genetics , gene , biology , in vitro
Background: Cytotoxic T lymphocyte antigen‐4 (CTLA‐4) is a T‐cell surface receptor of activated T cells. Material and methods: We studied 100 Iranian patients with clinically definite multiple sclerosis (MS) and 100 ethnic, sex‐ and age‐matched controls. CTLA‐4 exon 1 A/G polymorphism was compared amongst patients and controls. Results: There was no statistically significant difference in the allelic [odds ratio (OR): 1.19, confidence interval (CI) 95%: 0.76–1.85, P = 0.4] and genotypes (OR: 1.60, CI 95%: 0.911–2.824, P = 0.102) distribution amongst patients and controls. Also gender, course and progression index did not reveal any statistically significant differences in allele and genotype distribution of A/G polymorphism. Conclusion: As a non‐European patient population, our results are consistent with the major previous studies showing no significant associations between CTLA4 exon 1 polymorphism and neither MS nor any of its subtypes.