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Inflammation‐related genes and the risk of Parkinson’s disease: a multilocus approach
Author(s) -
Infante J.,
GarcíaGorostiaga I.,
SánchezJuan P.,
SánchezQuintana C.,
Gurpegui J. L.,
RodríguezRodríguez E.,
Mateo I.,
Berciano J.,
Combarros O.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02092.x
Subject(s) - parkinson's disease , medicine , tumor necrosis factor alpha , disease , inflammation , gene , interleukin 6 , neuroinflammation , association (psychology) , bioinformatics , oncology , genetics , biology , psychology , psychotherapist
For the first time, the multilocus approach by the set‐association method has been applied for the analysis of a cluster of five genes [tumor necrosis factor α (TNF‐α), interleukin 6 (IL‐6), IL‐8, IL‐1α and IL‐10] involved in the brain neuroinflammatory pathway in Parkinson’s disease (PD), in a well‐defined group of 197 PD patients and 173 control subjects from Spain. Set‐association analysis did not reveal an independent or an interactive effect of these inflammatory genes on the PD risk.