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Cerebrospinal fluid 14‐3‐3‐γ protein level in eight HIV‐negative cryptococcal meningitis adults
Author(s) -
Chang W. N.,
Lu C. H.,
Huang C. R.,
Chuang Y. C.,
Tsai N. W.,
Chen S. F.,
Chang C. C.,
Wang H. C.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2008.02091.x
Subject(s) - cerebrospinal fluid , medicine , csf albumin , cryptococcal meningitis , meningitis , white blood cell , neuroimaging , gastroenterology , human immunodeficiency virus (hiv) , pathology , immunology , pediatrics , viral disease , psychiatry
The clinical data and cerebrospinal fluid (CSF) 14‐3‐3‐γ protein detection of eight adult HIV‐negative cryptococcal meningitis (CM) cases were examined. The eight cases included six males and two females aged 35–70 years (mean = 49.8 years). The duration between the onset of CM symptoms and the first CSF study ranged from 1 to 60 days. Initial neuroimaging study was abnormal in 87.5% (7/8) of the cases. All the eight had positive initial and subsequent follow‐up CSF 14‐3‐3‐γ protein detection. The densitometric values of CSF 14‐3‐3‐γ protein were not correlated with either the CSF white blood cell counts or the therapeutic results. The therapeutic results showed that three cases died and five survived. Significant neurologic deficits were shown in 60% (3/5) of the survivors. This study revealed that HIV‐negative CM patients have elevated CSF 14‐3‐3‐γ protein levels, and that this level is not changed with a short‐term treatment.