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Mortality in multiple sclerosis: a review
Author(s) -
Ragonese P.,
Aridon P.,
Salemi G.,
D’Amelio M.,
Savettieri G.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2007.02019.x
Subject(s) - medicine , multiple sclerosis , clinical neurology , physical medicine and rehabilitation , intensive care medicine , neuroscience , psychiatry , biology
This work was undertaken to evaluate studies on mortality caused by multiple sclerosis (MS), to evaluate if useful inferences can be drawn from survival studies that can be applied to clinical practice. A literature search was carried out to find epidemiological studies on MS prognosis, survival, mortality and causes of death relevant to our aim. The World Health Organization (WHO) reports on worldwide cause‐specific mortality were also considered. Studies were evaluated according to the duration of the follow‐up study, the year of publication and the methodology used. We evaluated MS survival from a methodological point of view and considered if time trends could be drawn from study results. We conclude that mortality is only slightly higher in MS patients when compared with that in the general population. Mortality is higher particularly for older patients and those with longer disease duration.