Premium
Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer’s disease patients’ brain regions
Author(s) -
Járdánházy A.,
Járdánházy T.,
Kálmán J.
Publication year - 2008
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2007.02016.x
Subject(s) - medicine , electroencephalography , cerebral blood flow , perfusion , sodium lactate , sodium , cardiology , alzheimer's disease , disease , endocrinology , anesthesia , chemistry , psychiatry , organic chemistry
Bilateral temporo‐parietal hypoperfusion and decreased glucose metabolism are characteristic in vivo findings in Alzheimer’s disease (AD). Lactate is a metabolic vasodilator and is known to induce increased cerebral blood flow in healthy adults. The present study addresses the issue whether sodium lactate infusion affects functional state and resulting electroencephalographic patterns of AD patients. Twelve late‐onset sporadic AD probands participated in this self‐control study. The relative power and synchronization likelihood (SL) values of the electroencephalographic samples were calculated and compared off‐line before and after sodium lactate infusion (0.5 m , 5 ml/kg body weight). Based on the reactivity to sodium lactate the scalp could be divided into three parts; no significant changes were seen in the seriously damaged (P3–P4) areas. The moderately affected regions in the close neighborhood showed a paradoxic inactivation with electroencephalographic slowing, a likely consequence of the metabolic‐like steal effect of the near‐normal areas outside. These results indicate a diminished vascular and/or metabolic reserve capacity to sodium lactate challenge in AD and confirm the formerly described electroencephalographic abnormalities.