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Motor neuron disease associated with non‐fluent rapidly progressive aphasia: case report and review of the literature
Author(s) -
Da Rocha A. J.,
Valério B. C. O.,
Buainain R. P.,
Ferraz M. E.,
Da Silva C. J.,
Maia Jr. A. C. M.,
Andrade V. P.,
Lancellotti C. L. P.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2007.01912.x
Subject(s) - medicine , aphasia , motor neuron , disease , neuroscience , physical medicine and rehabilitation , psychiatry , pathology , psychology
The superimposed clinical features of motor neuron disease (MND) and frontotemporal lobar degeneration (FTLD) comprise a rare neurological overlap syndrome that represents a diagnostic challenge to neurologists. Currently, FTLD‐MND is considered a distinct entity and its clinicopathological basis has recently been reviewed. Our aim is to present a patient with MND and non‐fluent rapidly progressive aphasia with clinical, imaging and histopathological correlation, as well as a brief review of the literature. We demonstrated the selective corticospinal tract (CST) and temporal lobe involvement using T 1 spin‐echo with an additional magnetization transfer contrast pulse on resonance (T 1 SE/MTC) and FLAIR MR sequences in our patient, with further clinical and histopathological correlation. To the best of our knowledge, there is no description about the use of these particular MR sequences in the evaluation of FTLD‐MND patients.