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No association of the ‐105 promoter polymorphism of the selenoprotein S encoding gene SEPS1 with cerebrovascular disease
Author(s) -
Hyrenbach S.,
Pezzini A.,
Del Zotto E.,
Giossi A.,
Lichy C.,
Kloss M.,
Werner I.,
Padovani A.,
Brandt T.,
GrondGinsbach C.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2007.01898.x
Subject(s) - medicine , allele , gene , ischemic stroke , polymorphism (computer science) , disease , stroke (engine) , exon , genotype , gastroenterology , oncology , genetics , biology , ischemia , mechanical engineering , engineering
A common pro‐inflammatory promoter variant of the selenoprotein S encoding gene (SEPS1) was studied in young stroke patients from Italy and Germany and in healthy control subjects. The ‐105A‐allele was found in 56 of 205 (27.3%) patients with ischemic stroke IS because of a spontaneous cervical artery dissection (CAD), and in 69 of 295 (23.4%) patients <50 years with IS of non‐CAD origin. The SEPS ‐105A promoter variant was detected in 87 of 393 healthy control subjects (22.1%) and in 11 of 55 CAD patients without IS (20%). The non‐significant differences of SEPS1 allele frequencies between disease groups and healthy controls suggest that the SEPS1 ‐105A allele is not a major‐risk factor for stroke.