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The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease
Author(s) -
Kalinderi K.,
Fidani L.,
Bostantjopoulou S.,
Katsarou Z.,
Kotsis A.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2007.01867.x
Subject(s) - lrrk2 , medicine , parkinson's disease , etiology , disease , mutation , cohort , pediatrics , genetics , gene , biology
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 2% of the population >60 years of age. Although, the etiology of PD is still unknown, the genetic background of the disease has been documented. Recently, a mutation in the LRRK2 gene, G2019S, was associated with 3–41% and 1–2% of familial and sporadic PD, respectively suggesting a pivotal role of LRRK2 in PD. In this report, we examine the association of the G2019S mutation with sporadic late‐onset PD, in an independent cohort of Greek patients and controls.