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Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility
Author(s) -
McCallum L. K.,
Fernandez F.,
Quinlan S.,
Macartney D. P.,
Lea R. A.,
Griffiths L. R.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2007.01800.x
Subject(s) - migraine , dopamine transporter , aura , migraine with aura , variable number tandem repeat , medicine , dopamine , genetic association , allele , genetics , gene , genotype , single nucleotide polymorphism , biology , dopaminergic
Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable number tandem repeat (VNTR) in intron 8 of the dopamine transporter gene (DAT Int8 ) in 550 migraine cases (401 with aura, 149 without aura) and 550 non‐migraine controls. Chi‐squared analysis of the DAT Int8 revealed that the allele and genotype frequency distributions for migraine cases (including subtype analysis) and controls were not different ( P > 0.1). These findings offer no evidence for an association of the DAT Int8 with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk.