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Effect of gabapentin on oculomotor control and parkinsonism in patients with progressive supranuclear palsy
Author(s) -
Poujois A.,
Vidailhet M.,
Trocello J.M.,
Bourdain F.,
Gaymard B.,
RivaudPéchoux S.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2007.01687.x
Subject(s) - gabapentin , progressive supranuclear palsy , medicine , saccade , parkinsonism , antisaccade task , physical medicine and rehabilitation , oculomotor nerve palsy , anesthesia , audiology , eye movement , ophthalmology , palsy , atrophy , alternative medicine , disease , pathology
The efficacy of gabapentin on motor, oculomotor and frontal lobe symptoms was evaluated in patients with progressive supranuclear palsy (PSP) in a pilot study. Fourteen patients were included and seven of them received gabapentin. Clinical evaluation and horizontal eye movement recordings were performed at inclusion and 5‐weeks later. Motor score and saccade latency in the visually guided saccade (VGS) task were identical in the two groups. However, the error rate in the antisaccade task was significantly decreased in the gabapentin group. This preliminary study shows that gabapentin improves reflexive saccade inhibition in patients with PSP but does not improve the latency of VGSs.