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Triggered C‐reactive protein (CRP) concentrations and the CRP gene −717A>G polymorphism in acute stroke or transient ischemic attack
Author(s) -
BenAssayag E.,
ShenharTsarfaty S.,
Bova I.,
Berliner S.,
Shopin L.,
Peretz H.,
Usher S.,
Shapira I.,
Bornstein N. M.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01661.x
Subject(s) - medicine , c reactive protein , genotype , acute stroke , polymorphism (computer science) , stroke (engine) , basal (medicine) , gastroenterology , ischemic stroke , gene polymorphism , acute phase protein , allele , cardiology , gene , ischemia , inflammation , tissue plasminogen activator , biology , biochemistry , mechanical engineering , insulin , engineering
C‐reactive protein (CRP) increases following an acute stroke/transient ischemic attack (TIA), but the increment level varies among patients. We analyzed CRP concentrations during an acute stroke/TIA in relation to the CRP gene −717A>G polymorphism. Six months following an acute ischemic stroke/TIA, basal concentrations of CRP were measured in 507 controls and 219 patients and were found to be unassociated with the CRP −717A>G polymorphism. However, during the acute phase of stroke/TIA, individuals with the AG/GG genotype had significantly elevated CRP concentrations as opposed to those with the AA genotype (2.02 ± 1.59 vs. 1.73 ± 1.69 mg/l, P = 0.027). In addition, significant 3.22‐fold increments in CRP concentrations was noted in individuals carrying the −717G allele when comparing the acute phase with the basal state of each patient and averaging the results. CRP −717A>G polymorphism is associated with triggered CRP concentrations during acute stroke/TIA. These findings might shed more light on the mechanisms of CRP elevation in acute ischemic stroke/TIA.