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The influence of anaemia on stroke prognosis and its relation to N‐terminal pro‐brain natriuretic peptide
Author(s) -
Nybo M.,
Kristensen S. R.,
Mickley H.,
Jensen J. K.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01591.x
Subject(s) - medicine , stroke (engine) , heart failure , logistic regression , cardiology , natriuretic peptide , odds ratio , anemia , brain natriuretic peptide , renal function , n terminal pro brain natriuretic peptide , mechanical engineering , engineering
Anaemia is a negative prognostic factor for patients with heart failure and impaired renal function, but its role in stroke patients is unknown. Furthermore, anaemia has been shown to influence the level of N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), but this is only investigated in patients with heart failure, not in stroke patients. Two‐hundred‐and‐fifty consecutive, well‐defined ischemic stroke patients were investigated. Mortality was recorded at 6 months follow‐up. Anaemia was diagnosed in 37 patients (15%) in whom stroke severity was worse than in the non‐anaemic group, whilst the prevalence of renal affection, smoking and heart failure was lower. At 6 months follow‐up, 23 patients were dead, and anaemia had an odds ratio of 4.7 when adjusted for age, Scandinavian Stroke Scale and a combined variable of heart and/or renal failure and/or elevation of troponin T using logistic regression. The median NT‐proBNP level in the anaemic group was significantly higher than in the non‐anaemic group, and in a multivariate linear regression model, anaemia remained an independent predictor of NT‐proBNP. Conclusively, anaemia was found to be a negative prognostic factor for ischemic stroke patients. Furthermore, anaemia influenced the NT‐proBNP level in ischemic stroke patients, an important aspect when interpreting NT‐proBNP in these patients.