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Decreased cerebral blood flow velocity in apolipoprotein E ɛ 4 allele carriers with mild cognitive impairment
Author(s) -
Sun Z.W.,
Zhu Y.X.,
Liu H.Y.,
Liu J.,
Zhu X.Q.,
Zhou J.N.,
Liu R.Y.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01579.x
Subject(s) - medicine , cerebral blood flow , cardiology , apolipoprotein e , transcranial doppler , allele , cognitive impairment , cerebral arteries , disease , genetics , biology , gene
The aim of this study was to investigate the changes in cerebral blood flow velocity (CBFV) and its relation to apolipoprotein E (apoE) ɛ 4 allele in mild cognitive impairment (MCI). Thirty MCI and 30 controls were assessed using Mini‐Mental State Examination (MMSE) and Cambridge Cognitive Examination‐Chinese version (CAMCOG‐C), and then insonated in the anterior (ACA), middle (MCA) and basilar (BA) cerebral arteries using transcranial Doppler ultrasonography. Compared with controls, MCI showed significant decreases in the mean ( V m ), systolic ( V s ) and diastolic ( V d ) CBFV, bilaterally in MCA and ACA ( P < 0.05–0.001), but not in BA. Compared with 17 apoE ɛ 4 allele non‐carriers, 13 carriers in MCI showed significant CBFV decreases, bilaterally in MCA ( P < 0.05–0.001). Our findings, the decreased CBFV in apoE ɛ 4 allele carriers with MCI, suggest that a large sample and longitudinal study in CBFV and cognitive changes may have the implications on early diagnosis of Alzheimer's disease.