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Relevance of 10‐min delayed recall in dementia screening
Author(s) -
De Rotrou J.,
BattalMerlet L.,
Wenisch E.,
Chausson C.,
Bizet E.,
Dray F.,
Lenoir H.,
Rigaud A.S.,
Ha O.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01578.x
Subject(s) - medicine , dementia , recall , context (archaeology) , memory clinic , ambulatory , cohort , prospective cohort study , neuropsychology , neuropsychological test , mini–mental state examination , cognition , audiology , disease , psychiatry , psychology , paleontology , cognitive psychology , biology
Within the context of early diagnosis of Alzheimer's disease (AD), there is a growing interest in neuropsychological screening tests. Amongst these tests, we focused on the largely used Memory Impairment Screen (MIS). The objective of the present work was to show that adding a 10‐min delayed recall to the MIS, improves the test psychometric characteristics in order to detect dementia in the earliest stages. A prospective study was carried out on a cohort of 270 consecutive elderly ambulatory subjects attending the Broca Hospital Memory Clinic: normal controls ( n = 67), mild cognitive impairment subjects ( n = 98) and mildly demented patients [ n = 105, Mini Mental State Examination (MMSE) = 23 ± 4]. This study consisted in testing the advantage of the 10‐min delayed recall entitled MIS‐D compared with the MIS. At a cut‐off score of 6, the MIS‐D revealed satisfying psychometric characteristics with a sensitivity of 81% and a specificity of 91%, whilst the MIS alone indicated a sensitivity of 60% and a specificity of 88% in detecting dementia. In demented patients with MMSE score ≥26, MIS‐D properties still remained satisfying (sensitivity: 75%, specificity: 92%). MIS‐D is a more relevant screening test than MIS alone at very early stages of dementia.