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Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies and the Movement Disorder Society–European Section. Part I: early (uncomplicated) Parkinson's disease
Author(s) -
Horstink M.,
Tolosa E.,
Bonuccelli U.,
Deuschl G.,
Friedman A.,
Kanovsky P.,
Larsen J. P.,
Lees A.,
Oertel W.,
Poewe W.,
Rascol O.,
Sampaio C.
Publication year - 2006
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01547.x
Subject(s) - medicine , medline , cochrane library , parkinsonism , disease , evidence based medicine , disease management , systematic review , movement disorders , scientific evidence , parkinson's disease , psychiatry , physical therapy , physical medicine and rehabilitation , intensive care medicine , alternative medicine , pathology , philosophy , epistemology , political science , law
The aim of the study was to provide evidence‐based recommendations for the management of early (uncomplicated) Parkinson's disease (PD), based on a review of the literature. Uncomplicated PD refers to patients suffering from the classical motor syndrome of PD only, without treatment‐induced motor complications and without neuropsychiatric or autonomic problems. MEDLINE, Cochrane Library and International Network of Agencies for Health Technology Assessment (INAHTA) database literature searches were conducted. National guidelines were requested from all European Federation of Neurological Societies (EFNS) societies. Non‐European guidelines were searched for using MEDLINE. Part I of the guidelines deals with prevention of disease progression, symptomatic treatment of motor features (parkinsonism), and prevention of motor and neuropsychiatric complications of therapy. For each topic, a list of therapeutic interventions is provided, including classification of evidence. Following this, recommendations for management are given, alongside ratings of efficacy. Classifications of evidence and ratings of efficacy are made according to EFNS guidance. In cases where there is insufficient scientific evidence, a consensus statement (good practice point) is made.