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Peripheral large nerve fibre function in patients with chronic plaque psoriasis
Author(s) -
Chroni E.,
Georgiou S.,
Polychronopoulos P.,
Sagriotis A.,
Monastirli A.,
Pasmatzi E.,
Tsambaos D.
Publication year - 2007
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01522.x
Subject(s) - medicine , psoriasis , peripheral , peripheral neuropathy , concomitant , pathogenesis , physical examination , neurophysiology , neurological examination , sensory nerve , nerve conduction , sensory system , dermatology , pathology , surgery , diabetes mellitus , neuroscience , endocrinology , psychiatry , biology
Accumulating evidence suggests the involvement of neurogenic inflammation in the pathogenesis of psoriasis. Moreover, the concomitant occurrence of peripheral neuropathy has been reported in several psoriatic patients. Thus, the aim of the present study was to answer the question whether an impairment of peripheral large nerve fibre function may exist in psoriasis. Thirty‐two patients with severe and generalized chronic plaque psoriasis and 32 sex‐ and age‐matched healthy controls were evaluated by detailed clinical neurological and standard neurophysiological examination. The latter included motor nerve conduction study of one nerve in the upper and one in the lower extremities and sensory nerve conduction study of one nerve in the upper and two in the lower extremities. Neurological examination failed to demonstrate any clinical evidence of large fibre neuropathy. Furthermore, all values of the examined neurophysiological parameters were within normal limits; comparisons of the corresponding mean values in the patient and the control group showed no statistically significant differences. These findings demonstrate no measurable abnormalities of the peripheral large nerve fibres in psoriatic patients and therefore an association of psoriasis with peripheral large fibre neuropathy cannot be suggested.