Premium
Expression of chemokine receptors on peripheral blood mononuclear cells of patients with immune‐mediated neuropathies treated with intravenous immunoglobulins
Author(s) -
Trebst C.,
Brunhorn K.,
Lindner M.,
Windhagen A.,
Stangel M.
Publication year - 2006
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01521.x
Subject(s) - chemokine receptor , medicine , c c chemokine receptor type 6 , immunology , ccr1 , cxcr3 , ccl13 , cc chemokine receptors , ccr2 , ccr4 , chemokine , cxcl13 , immune system , chemokine receptor ccr5 , multifocal motor neuropathy , mismatch negativity , electroencephalography , psychiatry
Intravenous immunoglobulin (IVIg) is an efficacious treatment for immune‐mediated neuropathies like Guillain–Barré syndrome (GBS), chronic inflammatory demyelinating neuropathy (CIDP), and multifocal motor neuropathy (MMN). In the pathogenesis of immune‐mediated neuropathies chemokines and their receptors play a crucial role. Using flow cytometry we examined whether IVIg modulates chemokine expression repertoires of T cells and monocytes. The expression of inflammatory chemokine receptors CCR1, CCR2, CCR4, CCR5, CCR6 and CXCR3 was investigated on circulating T‐cell subsets, and CCR1, CCR2 and CCR5 on circulating monocytes before and after IVIg treatment in patients with immune‐mediated neuropathies (MMN, n = 7; GBS, n = 1; CIDP, n = 2). Furthermore, the homing potential of T cells was analyzed by the expression of CCR7, a chemokine receptor known to be utilized by mature T cells to recirculate into secondary lymphoid organs. In contrast to studies in chronic heart failure, no differences in expression patterns before and after IVIg treatment of any of the investigated chemokine receptors were found. Furthermore, the proportion of CD45RO‐positive CD4 + or CD8 + T‐cell subsets was not changed by IVIg treatment. Thus, we concluded that modulation of the expression of chemokine receptors on circulating leukocytes by IVIg is not a mode of action in immune‐mediated neuropathies.