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Fatigue and sleep disturbance in multiple sclerosis
Author(s) -
Kaynak H.,
Altintaş A.,
Kaynak D.,
Uyanik Ö.,
Saip S.,
Ağaoğlu J.,
Önder G.,
Siva A.
Publication year - 2006
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01499.x
Subject(s) - pittsburgh sleep quality index , medicine , sleep (system call) , sleep disorder , depression (economics) , beck depression inventory , arousal , sleep debt , physical therapy , physical medicine and rehabilitation , sleep quality , insomnia , psychiatry , psychology , anxiety , neuroscience , macroeconomics , computer science , economics , operating system
Considering the association of sleep disturbance and fatigue in multiple sclerosis (MS), we investigated the presence of sleep disturbances that may be related to fatigue by using objective and subjective measures. We included 27 MS patients with fatigue, 10 MS patients without fatigue and 13 controls. The Pittsburgh sleep quality index score showed significant differences between patient groups and controls. Beck depression inventory scores were significantly higher in fatigued than non‐fatigued patients. Comparison of patient groups and controls revealed significant differences for time in bed, sleep efficiency index, sleep continuity index, wake time after sleep onset, total arousal index and periodic limb movement arousal index. Our study confirms that MS causes sleep fragmentation in terms of both macro and microstructure. Fatigue in MS could be partially explained by disruption of sleep microstructure, poor subjective sleep quality and depression.