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Analysis of the effect of aluminum in drinking water and transferrin C2 allele on Alzheimer's disease
Author(s) -
Rondeau V.,
Iron A.,
Letenneur L.,
Commenges D.,
Duchêne F.,
Arveiler B.,
Dartigues J.F.
Publication year - 2006
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01339.x
Subject(s) - apolipoprotein e , allele , transferrin , medicine , alzheimer's disease , genotype , disease , logistic regression , genetics , gene , biology
Although highly controversial, the hypothesis of a link between aluminum (Al) in drinking water and Alzheimer's disease (AD) has been supported by several epidemiological studies. Transferrin (Tf) is a major transport protein for both iron and Al. Moreover, it has been demonstrated that defective binding of iron and Al to the Tf variant C2 could be present in AD. Individuals carrying the Tf C2 allele might therefore be at greater risk of developing AD. We investigated whether the Tf C2 allele might be responsible for susceptibility to AD in a sample of 292 subjects (with 55 AD) aged ≥75 years from south‐west France, some exposed to high levels of Al in tap water ( n = 181 subjects) and others to low levels of Al ( n = 111 subjects). We also examined the combined genetic effects of Tf C2 and ɛ 4 allele of apolipoprotein E gene (ApoE). Logistic regression analysis showed that neither Tf C2 nor its interaction with Al or with the ɛ 4 allele of the ApoE were significantly associated with the risk of AD.