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Evidence of familial syringomyelia in discordant association with Chiari type I malformation
Author(s) -
Robenek M.,
Kloska S. P.,
Husstedt I. W.
Publication year - 2006
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2006.01285.x
Subject(s) - syringomyelia , medicine , magnetic resonance imaging , chiari malformation , sister , syrinx (medicine) , radiology , sociology , anthropology
We report a sister and two half brothers who presented with magnetic resonance imaging (MRI)‐proven syringomyelia and associated Chiari type I malformation in two cases. The individuals have the same mother but two different fathers. The mother shows no clinical signs of syringomyelia. The two fathers died through unknown causes. In a third healthy son of the mother by a relationship with a third father syringomyelia was excluded by MRI. We believe that an autosomal‐dominant predisposition is the primary factor in the appearance of syringomyelia in these cases.