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Common genetic variants of homocysteine metabolism in ischemic stroke: a case–control study
Author(s) -
Linnebank M.,
Montenarh M.,
Kölsch H.,
Linnebank A.,
Schnez K.,
Schweichel D.,
Pohl C.,
Urbach H.,
Heun R.,
Harbrecht U.,
Klockgether T.,
Wüllner U.
Publication year - 2005
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2005.01045.x
Subject(s) - methylenetetrahydrofolate reductase , medicine , hyperhomocysteinemia , homocysteine , odds ratio , stroke (engine) , risk factor , case control study , ischemic stroke , genotype , gastroenterology , bioinformatics , ischemia , genetics , biology , gene , engineering , mechanical engineering
Hyperhomocysteinemia is a risk factor for ischemic stroke. We investigated five functional polymorphisms involved in homocysteine metabolism in each 159 stroke patients and controls. The folate‐sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non‐significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 ± 3 years vs. 45 ± 1 years; P = 0.043). This study suggests that the investigated polymorphisms are no major risk factors for stroke, although MTHFR c. 677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work‐up of stroke cases and for preventive dietary strategies.