Premium
Trousseau's syndrome related to adenocarcinoma of the colon and cholangiocarcinoma
Author(s) -
Tasi S.H.,
Juan C.J.,
Dai M.S.,
Kao W.Y.
Publication year - 2004
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.2004.00814.x
Subject(s) - medicine , malignancy , coagulopathy , colorectal cancer , adenocarcinoma , cerebral infarction , disease , cancer , myocardial infarction , gastroenterology , ischemia
Malignancy‐related thromboembolism, so‐called Trousseau's syndrome, can present as acute cerebral infarction, non‐bacterial thrombotic endocarditis (NBTE) and migratory thrombophlebitis. It is usually attributed to a cancer‐related hypercoagulable state, chronic disseminated intravascular coagulopathy (DIC), or tumour embolism. We report on two patients with adenocarcinoma of the colon and cholangiocarcinoma who developed widespread thromboembolism during disease progression. Both did poorly despite aggressive institution of anticoagulation therapy. These cases emphasize that cerebral infarction or refractory thromboembolism in cancer‐treated patients should prompt investigation for recurrent or metastatic disease or progression of the underlying malignancy. Optimal treatment remains to be established.