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Lupus anticoagulant and Sneddon's syndrome
Author(s) -
Lousa M.,
Gobernado J. M.,
Cervero C.,
PerezCorral F.,
Pardo A.
Publication year - 1997
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.1997.tb00370.x
Subject(s) - medicine , lupus anticoagulant , thrombosis , anticardiolipin antibodies , serology , systemic lupus erythematosus , antiphospholipid syndrome , anticoagulant , gastroenterology , antibody , immunology , dermatology , disease
We present the coagulation and serological studies of four patients with Sneddon's syndrome, in which antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulant) were determined using cardiolipin and a mixture of phospholipid from rabbit brain as antigen for detection of lupus anticoagulant by ELISA. Our results support a relation between Sneddon's syndrome and lupus anticoagulant (IgG subtype) in all cases. The anticardiolipin antibody test was positive only in two cases (one in low level). All patients could be diagnosed as having primary antiphospholipid antibody syndrome. Antiaggregant treatment was not effective in preventing thrombosis in two cases. Three of four patients received long‐term oral anticoagulation therapy, with no recurrence of thrombosis observed for a period of at least 3 years.