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Changes in cerebral glucose metabolism with normal aging
Author(s) -
Blesa R.,
Mohr E.,
Miletich R. S.,
Randolph C.,
Hildebrand K.,
Sampson M.,
Chase T. N.
Publication year - 1997
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.1997.tb00294.x
Subject(s) - medicine , atrophy , carbohydrate metabolism , cerebral atrophy , brain aging , metabolism , neuroscience , endocrinology , biology , disease
The pattern of changes in cerebral glucose metabolism occurring with normal aging has been unclear. Advances in imaging technology, such as improved resolution and anatomical referencing, allow for more precise regional measurement than previously possible. This study explored cerebral glucose metabolism in 17 normal controls ranging in age from 20 to 74 years. High resolution PET scanning, with MRI‐based regions of interest correcting for partial volume and atrophy effects, revealed a linear association between advancing age and declining cerebral glucose metabolism. The decline averaged 8% per decade for the whole brain. Changes were most pronounced in limbic structures, and could be implicated in age‐associated memory loss.