Premium
Chronic immune‐related demyelinating neuropathies
Author(s) -
Nemni R.,
Sessa M.
Publication year - 1996
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.1996.tb00420.x
Subject(s) - chronic inflammatory demyelinating polyneuropathy , medicine , myelin , autoantibody , immune system , demyelinating disorder , immunology , multifocal motor neuropathy , antigen , neuroscience , multiple sclerosis , antibody , central nervous system , biology , mismatch negativity , electroencephalography , psychiatry
In recent years many important advances have been made in the knowledge of the mechanisms that may produce peripheral nerve damage. Data in the literature indicate that in some chronic demyelinating neuropathy autoantibodies against myelin antigens may play a pathogenic role. The pathogenic role of T cells, cytokines, complement, and class II molecules has also been studied. Identification of specific immune‐related demyelinating polyneuropathies provides clues to future therapeutic approaches. This paper focuses on the chronic inflammatory demyelinating polyneuropathy, chronic demyelinating neuropathies associated with monoclonal gammapathies of undetermined significance, and multifocal motor neuropathy, and reviews their clinical, patophysiological and immunological features.