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Evaluation of interleukin 10 and interferon‐α in the cerebrospinal fluid and serum of patients with multiple sclerosis
Author(s) -
Carrieri P. B.,
Maiorino A.,
Provitera V.,
Perrella A.,
Perrella O.
Publication year - 1996
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.1996.tb00271.x
Subject(s) - multiple sclerosis , medicine , cerebrospinal fluid , interferon , cytokine , interleukin , immunology
The activities of IL‐10, a cytokine produced by TH2 cells, monocytes and B‐cells, and IFN‐α, a product of activated macrophages/monocytes, were investigated in the CSF and serum samples of 25 subjects with clinically definite multiple sclerosis (MS), of whom 14 were in the active and nine in the stable phase, and of 15 controls with other noninflammatory neurological diseases (OND). Elevated CSF IL‐10 and IFN‐α levels were found in MS patients in the stable phase with respect to patients in the active phase ( p > 0.001), while no significant differences were observed in the mean serum levels between MS patients (both in the active and stable phase) and controls. Finally, a significant correlation was detected between IL‐10 and IFN‐α in the CSF of MS patients in remission. This study suggests that IL‐10 may downregulate MS progression.