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Mixed germ cell tumour of the central nervous system with multiple metastases—a 5‐year history. A case report
Author(s) -
Áfra J.,
Jelencsik I.,
Gyergyai F.,
Slowik F.,
Kenéz J.
Publication year - 1996
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.1996.tb00195.x
Subject(s) - medicine , germinoma , radiation therapy , chemotherapy , teratoma , germ cell tumors , surgery , pathology
After a 4‐month history of intermittent headache an intrasellar benign teratoma was found and totally removed in a 19‐year‐old male patient who became symptom‐free. Three years later a third ventricle germinoma developed which was also totally removed, followed by local radiotherapy. Eight months later a spinal tumour evolved, chemotherapy and radiotherapy resulted in full recovery. Eighteen months later a frontal meningeal tumour appeared and was treated by chemotherapy. Three months later—with chemotherapy—tumorous meningitis developed and the patient died 5 years after the first operation. The results of tumour‐markers monitoring, histology, electronmicroscopy and immunohistochemistry referred to a germinoma with multiple metastases and meningeal seeding after total removal of an intrasellar mature teratoma.