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Multiple cerebral hemorrhages as a possible complication of antiblastic treatment with cyclophosphamide, methotrexate and fluoruracil (CMF) for breast cancer
Author(s) -
Maggioni F.,
Rossi P.,
Zanchin G.
Publication year - 1995
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.1995.tb00156.x
Subject(s) - medicine , cyclophosphamide , methotrexate , breast cancer , chemotherapy , complication , mastectomy , oncology , surgery , cancer
In this paper we describe the case of a patient who underwent left breast radical mastectomy and corresponding removal of her axillary lymphonodes, for an infiltrating lobular cancer with massive colonizing (16 of 19 lymphonodes examined), stage T2N2M0. During chemotherapy with cyclophosphamide, methotrexate and 5 fluoruracil (CMF), the patient presented a symptomatology characterized by anarthria and dysphagia. These symptoms were the consequences of multiple cerebral hemorrhages unrelated to alterations in the coagulation process. The temporal relation with the pharmacological treatment and the lack of other explanations of the induced phenomenon lead us to hypothesize a cytotoxic mechanism due to the CMP treatment