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Impaired water metabolism and cerebral oedema following experimental subarachnoid haemorrhage in rats 1
Author(s) -
László A.,
Varga C.,
Dóczi T.
Publication year - 1995
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.1995.tb00118.x
Subject(s) - medicine , vasopressin , cerebrospinal fluid , subarachnoid hemorrhage , hyponatremia , cerebral edema , anesthesia , brain edema , subarachnoid haemorrhage , body water , endocrinology , surgery , aneurysm , body weight
The acute phase of subarachnoid haemorrhage (SAH) is frequently associated with an impaired water metabolism and a disposition to cerebral oedema. For study of the pathogenesis of brain oedema following SAH, an experimental model of SAH was created in the rat The diuretic curves after water loading, the brain water and electrolyte contents and the plasma and cerebrospinal fluid arginine vasopressin (AVP) levels were examined in rats with SAH. Following a water load, a significant water retention and increases in brain water and sodium contents were observed after subarachnoid bleeding. Plasma and cerebrospinal fluid AVP levels were also elevated following SAH. It can be concluded that AVP plays important roles in the development of antidiuresis after water loading and in the disturbance of the brain water and electrolyte balance following experimental SAH.