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Decreased CSF levels of homovanillic acid in ALS patients
Author(s) -
Testa D.,
Colangelo A.M.,
Fetoni V.,
Parati E.
Publication year - 1995
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/j.1468-1331.1995.tb00089.x
Subject(s) - homovanillic acid , amyotrophic lateral sclerosis , medicine , cerebrospinal fluid , dopaminergic , lumbar , lumbar puncture , dopamine , endocrinology , anesthesia , disease , surgery , receptor , serotonin
Levels of homovanillic acid (MVA) were measured in lumbar cerebrospinal fluid from 24 patients affected by amyotrophic lateral sclerosis (ALS) and compared with those found in 11 patients with Parkinson's disease (PD) and 10 patients with lumbar disc herniations who served as controls. Mean HVA levels were significantly decreased in ALS and PD patients. These findings are consistent with impairment of central dopaminergic systems in ALS as well as suggesting degeneration of neuroanatomical structures other than motor neurons.