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Interleukin‐17 regulates visceral obesity in HIV‐1‐infected patients
Author(s) -
Zizza A,
Guido M,
Grima P
Publication year - 2012
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/j.1468-1293.2012.01014.x
Subject(s) - medicine , adipose tissue , waist , obesity , visceral fat , body mass index , gastroenterology , intra abdominal fat , human immunodeficiency virus (hiv) , endocrinology , immunology , insulin resistance
Objective The aim of the study was to evaluate the interleukin‐17 ( IL ‐17) plasma level in HIV ‐1‐infected patients and its relation to central obesity. Methods Eighty‐four HIV ‐1‐infected patients [42 with visceral obesity (group A ) and 42 without visceral obesity (group B )] and 46 HIV ‐negative subjects [23 with visceral obesity (group C ) and 23 without visceral obesity (group D )] were enrolled in the study. Sonographic measurements of perirenal fat diameter/body mass index ( PRFD / BMI ) were used to assess visceral adipose tissue thickness. Results HIV ‐1‐infected patients had higher plasma levels of IL ‐17 than HIV ‐negative subjects [837.8 ± 260 pg/mL (mean ± standard deviation) vs . 395.3 ± 138.6 pg/mL , respectively; P < 0.001]. Furthermore, HIV ‐1‐infected patients with a diagnosis of visceral obesity had lower levels of IL ‐17 than HIV ‐infected lean patients (756.9 ± 282.9 pg/mL vs . 918.7 ± 208.4 pg/mL , respectively; P < 0.01). IL ‐17 ( r = −0.21; P = 0.03) and waist circumference ( r = 0.48; P < 0.001) were significantly associated with visceral adipose tissue thickness. A negative correlation of IL ‐17 ( r = −0.23; P < 0.001) with PRFD / BMI was found. Conclusions This study suggests a linear negative association between IL ‐17 and visceral adipose tissue thickness.