Premium
Improved strategies for HIV diagnosis among men who have sex with men ( MSM ) in B uenos A ires, A rgentina, a population with a high prevalence and incidence of HIV infection
Author(s) -
Pando MA,
Coloccini RS,
Schvachsa N,
Pippo M,
Alfie LG,
Marone R,
GomezCarrillo M,
Avila MM,
Salomón H
Publication year - 2012
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/j.1468-1293.2012.01011.x
Subject(s) - medicine , men who have sex with men , population , human immunodeficiency virus (hiv) , immunology , environmental health , syphilis
Background In A rgentina, HIV diagnosis in adults is made using one or two enzyme immunoassay tests and a confirmatory test. These strategies may fail to identify infected individuals during early primary infection, which represents an important public health problem among groups with a high HIV incidence, such as men who have sex with men ( MSM ) (6.3% persons/year). The general objective of this study was to contribute to reducing HIV transmission among MSM through the identification of antibody‐negative, nucleic acid‐positive individuals. Findings A total of 1549 MSM were recruited for an HIV seroprevalence study. A total of 161 (10.4%) MSM were HIV ‐positive and 14 (0.9%) were indeterminate. Among the 1374 negative individuals, 16 (1.2%) exhibited reactive results in the screening assay. Indeterminate Western blot ( WB ) samples and negative WB samples (with discordant results in the screening) were analysed to detect HIV nucleic acid by viral load testing. Up to 23.1% of HIV ‐indeterminate WB samples and 7.1% of HIV ‐negative WB samples with discordant results in the screening assays had detectable nucleic acid. Overall, 14.8% of the samples with discordant or indeterminate results were identified as HIV ‐positive using direct diagnosis. With the identification of four new cases using the nucleic acid detection test, the HIV prevalence in MSM increased by 0.3% (from 10.4 to 10.7%). Conclusions The results of this study suggest the importance of including nucleic acid detection in the HIV algorithm for MSM with HIV ‐indeterminate WB results and those with HIV ‐negative WB results and discordant results in screening assays, in order to decrease HIV transmission among this population with a high HIV prevalence and incidence.