Premium
Zinc alpha‐2 glycoprotein is implicated in dyslipidaemia in HIV ‐1‐infected patients treated with antiretroviral drugs
Author(s) -
CeperueloMallafré V,
Escoté X,
Viladés C,
Peraire J,
Domingo P,
Solano E,
Sirvent JJ,
Pastor R,
Tinahones F,
Leal M,
Richart C,
Vendrell J,
Vidal F
Publication year - 2012
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/j.1468-1293.2011.00976.x
Subject(s) - lipodystrophy , medicine , metabolic syndrome , insulin resistance , adipokine , endocrinology , regimen , cholesterol , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load , insulin , immunology , obesity
Objectives Treated HIV ‐1‐infected patients with lipodystrophy often develop insulin resistance and proatherogenic dyslipidaemia. Zinc alpha‐2 glycoprotein ( ZAG ) is a recently characterized adipokine which has been shown to be involved in the development of obesity and metabolic syndrome in uninfected subjects. We assessed the relationship between circulating ZAG levels and metabolic derangements in HIV ‐1‐infected patients receiving antiretroviral drugs. Methods Plasma ZAG levels were assessed in 222 individuals: 166 HIV ‐1‐infected patients treated with antiretroviral drugs (77 with lipodystrophy and 89 without lipodystrophy) and 56 uninfected controls. Plasma ZAG levels were assessed by enzyme‐linked immunosorbent assay ( ELISA ) and were correlated with fat distribution abnormalities and metabolic parameters. Results HIV ‐1‐infected patients had lower plasma ZAG levels compared with uninfected controls ( P < 0.001). No differences were found in ZAG plasma levels according to the presence of lipodystrophy, components of the metabolic syndrome or type of antiretroviral treatment regimen. Circulating ZAG levels were strongly determined by high‐density lipoprotein cholesterol ( HDLc ) in men ( B = 0.644; P < 0.001) and showed a positive correlation with total cholesterol ( r = 0.312; P < 0.001) and HDLc ( r = 0.216; P = 0.005). Conclusions HIV ‐1‐infected patients have lower plasma ZAG levels than uninfected controls. In infected patients, plasma ZAG levels are in close relationship with total cholesterol and HDLc .