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Cervical intraepithelial neoplasia and invasive cancer risks in women infected with HIV in the French West Indies
Author(s) -
Kadhel P,
Multigner L,
Bardinet F,
GoergerSow MT,
Janky E
Publication year - 2012
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/j.1468-1293.2011.00939.x
Subject(s) - medicine , west indies , cervical intraepithelial neoplasia , cervical cancer , human immunodeficiency virus (hiv) , gynecology , oncology , virology , cancer , ethnology , history
ObjectiveThe aim of the study was to assess whether HIV infection is associated with a higher risk of invasive cervical cancer (ICC).MethodsWe conducted a region‐wide, population‐based observational cohort study of 1232 HIV‐infected women over the age of 15 years in Guadeloupe, a French Caribbean archipelago, during the period 1999–2006. The observed numbers of incident cases of cervical intraepithelial neoplasia (CIN) and ICC were compared with the expected numbers of cases based on the incidence rates for the general population, and the standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated.ResultsThe incidence rate of CIN was higher in the HIV‐infected women than in the general population for all grades (SIR 10.1, 95% CI 6.8–14.6 for CIN grade 1; SIR 9.9, 95% CI 6.1–15.3 for CIN grade 2; and SIR 5.2, 95% CI 3.4–7.7 for CIN grade 3). However, no increase in the risk of ICC was observed (SIR 1.7, 95% CI 0.3–4.9).ConclusionsDespite an increase in the occurrence of cervical cancer precursors, no increase in the risk of cervical cancer was found in a population of HIV‐infected women who receive treatment for their infection and have access to ICC prevention services.