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Different distributions of hepatitis C virus genotypes among HIV‐infected patients with acute and chronic hepatitis C according to interleukin‐28B genotype
Author(s) -
Neukam K,
Nattermann J,
Rallón N,
Rivero A,
Caruz A,
Macías J,
Vogel M,
Benito JM,
Camacho Á,
Mira JA,
SchwarzeZander C,
Barreiro P,
Martínez A,
Rockstroh JK,
Soriano V,
Pineda JA
Publication year - 2011
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/j.1468-1293.2011.00912.x
Subject(s) - genotype , interleukin 28b , hepatitis c virus , medicine , virology , hepatitis c , hepacivirus , immunology , virus , biology , gene , ribavirin , genetics
Objectives The C allele of the single nucleotide polymorphism rs12979860, located near the interleukin‐28B ( IL‐28B ) gene, has a strong impact on hepatitis C virus (HCV) treatment response, as well as on spontaneous viral clearance. In patients with chronic hepatitis C (CHC), genotype CC carriers harbour HCV genotype 3 more commonly than those with non‐CC genotypes. The aim of this study was to compare the HCV genotype distributions, according to IL‐28B genotype, in HIV‐infected patients with CHC and those with acute hepatitis C (AHC). Methods The rs12979860 genotype was determined by polymerase chain reaction (PCR) in two subpopulations of HIV‐infected patients. The first consisted of 80 German patients with AHC. The second consisted of 476 patients with CHC, belonging to one German and two Spanish cohorts. Results In the AHC group, 31 (81.6%) rs12979860 CC carriers were infected with HCV genotype 1 or 4 vs . 32 (76.2%) among non‐CC carriers ( P =0.948). In patients with CHC, among those with the CC genotype, 119 (54.6%) were infected with HCV genotype 1 or 4 and 99 (45.4%) with genotype 2 or 3, whereas in the subset with non‐CC genotypes, 200 (77.5%) harboured HCV genotype 1 or 4 and 58 (22.5%) genotype 2 or 3 ( P <0.001). Conclusions Among HIV‐infected patients with CHC, those bearing the IL‐28B genotype CC were more commonly infected with genotype 3 than subjects with non‐CC genotypes, whereas in HIV‐infected subjects with AHC this finding was not obtained. These results strongly suggest that the protective effect of the CC genotype against evolution to CHC is mainly exerted in patients infected with HCV genotype 1 or 4.