Premium
The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV‐1‐associated dementia
Author(s) -
Pemberton LA,
Stone E,
Price P,
Van Bockxmeer F,
Brew BJ
Publication year - 2008
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/j.1468-1293.2008.00614.x
Subject(s) - medicine , allele , dementia , apolipoprotein e , tumor necrosis factor alpha , linkage disequilibrium , immunology , gene , gastroenterology , disease , genetics , haplotype , biology
Objectives Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods DNA from ADC patients ( n =56), unselected HIV‐seropositive patients ( n =112, 171, 185 and 204) and HIV‐seronegative controls ( n =204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)‐α, interleukin (IL)‐1α, IL‐1β, IL‐12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage ≥1 and CD4 counts of <500 cells/μL. Results Allele 2 of TNFA‐308 was more common in ADC patients compared to HIV‐positive or HIV‐negative controls ( P =0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta‐analyses confirmed these results. Conclusions This study suggests that TNFA‐308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC.