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The prevalence of transmitted antiretroviral drug resistance in treatment‐naïve patients and factors influencing first‐line treatment regimen selection
Author(s) -
Huang HY,
Daar ES,
Sax PE,
Young B,
Cook P,
Benson P,
Cohen C,
Scribner A,
Hu H
Publication year - 2008
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/j.1468-1293.2008.00561.x
Subject(s) - medicine , regimen , hiv drug resistance , drug resistance , odds ratio , confidence interval , reverse transcriptase inhibitor , drug , pill , dosing , virology , pharmacology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , biology , microbiology and biotechnology
Objectives To estimate the prevalence of transmitted antiretroviral (ARV) drug resistance, and to assess whether resistance testing influences first‐line ARV regimen selection. Methods Data on patients' characteristics were collected through questionnaires. ARV drug resistance was tested by genotypic methods and defined by Quest–Stanford classification rule. Physicians reported the intended and actual treatments and the factors considered in treatment selection. Results Two hundred and twenty‐eight patients were included. The prevalence of ARV drug resistance was 12.1%, with 9.8% for non‐nucleoside reverse transcriptase inhibitors (NNRTIs), 4.5% for nucleoside reverse transcriptase inhibitors and 1.8% for protease inhibitors (PIs). Pill burdens, dosing frequency and physicians' experience with regimens were the major factors considered in treatment selection. The intended and actual treatment differed for 73 and 44% of the patients with and without ARV drug resistance, respectively [odds ratio (95% confidence interval, CI)=3.6 (1.5–9.0), P =0.006]. NNRTI‐based regimens were intended for 10 patients with resistance to NNRTIs; these patients were prescribed PI‐based regimens after genotypic testing. Conclusions Transmitted ARV drug resistance was detected in 12.1% of treatment‐naïve patients, with resistance to NNRTIs the most common. Resistance‐testing results played a partial role in first‐line treatment selection. However, resistance to NNRTIs pre‐empted NNRTI use.