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The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy
Author(s) -
Parsonage MJ,
Wilkins EGL,
Snowden N,
Issa BG,
Savage MW
Publication year - 2005
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1111/j.1468-1293.2005.00318.x
Subject(s) - medicine , osteomalacia , fanconi syndrome , tenofovir , myopathy , context (archaeology) , antiretroviral therapy , drug , hypophosphatemia , human immunodeficiency virus (hiv) , vitamin d and neurology , pharmacology , kidney , immunology , viral load , paleontology , biology
We report two cases in which osteomalacia developed in patients on tenofovir‐containing highly active antiretroviral therapy (HAART) in the context of Fanconi syndrome with hypophosphataemia. Bone pain was the presenting feature and myopathy followed in one case. Disability was reversed with withdrawal of the drug and with mineral supplementation. The cases highlight the importance of considering the diagnosis of osteomalacia in patients treated with tenofovir. A possible association with incipient acute renal failure, particularly during nonsteroidal anti‐inflammatory drug (NSAID) use, needs further investigation.