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Statistics for weighing benefits and harms in a proposed genetic substudy of a randomized cancer prevention trial
Author(s) -
Baker Stuart G.,
Kramer Barnett S.
Publication year - 2005
Publication title -
journal of the royal statistical society: series c (applied statistics)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.205
H-Index - 72
eISSN - 1467-9876
pISSN - 0035-9254
DOI - 10.1111/j.1467-9876.2005.00522.x
Subject(s) - tamoxifen , breast cancer , randomized controlled trial , medicine , penetrance , population , oncology , cancer , genetics , gene , biology , environmental health , phenotype
Summary. When evaluating potential interventions for cancer prevention, it is necessary to compare benefits and harms. With new study designs, new statistical approaches may be needed to facilitate this comparison. A case in point arose in a proposed genetic substudy of a randomized trial of tamoxifen versus placebo in asymptomatic women who were at high risk for breast cancer. Although the randomized trial showed that tamoxifen substantially reduced the risk of breast cancer, the harms from tamoxifen were serious and some were life threaten‐ing. In hopes of finding a subset of women with inherited risk genes who derive greater bene‐fits from tamoxifen, we proposed a nested case–control study to test some trial subjects for various genes and new statistical methods to extrapolate benefits and harms to the general population. An important design question is whether or not the study should target common low penetrance genes. Our calculations show that useful results are only likely with rare high penetrance genes.