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Robust detection and identification of sparse segments in ultrahigh dimensional data analysis
Author(s) -
Tony Cai T.,
Jessie Jeng X.,
Li Hongzhe
Publication year - 2012
Publication title -
journal of the royal statistical society: series b (statistical methodology)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.523
H-Index - 137
eISSN - 1467-9868
pISSN - 1369-7412
DOI - 10.1111/j.1467-9868.2012.01028.x
Subject(s) - identification (biology) , computer science , pattern recognition (psychology) , artificial intelligence , data mining , botany , biology
Summary. Copy number variants (CNVs) are alternations of DNA of a genome that result in the cell having less or more than two copies of segments of the DNA. CNVs correspond to relatively large regions of the genome, ranging from about one kilobase to several megabases, that are deleted or duplicated. Motivated by CNV analysis based on next generation sequencing data, we consider the problem of detecting and identifying sparse short segments hidden in a long linear sequence of data with an unspecified noise distribution. We propose a computationally efficient method that provides a robust and near optimal solution for segment identification over a wide range of noise distributions. We theoretically quantify the conditions for detecting the segment signals and show that the method near optimally estimates the signal segments whenever it is possible to detect their existence. Simulation studies are carried out to demonstrate the efficiency of the method under various noise distributions. We present results from a CNV analysis of a HapMap Yoruban sample to illustrate the theory and the methods further.