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The great ambivalence: factors likely to affect service user and public acceptability of the pharmacogenomics of antidepressant medication
Author(s) -
Barr Michael,
Rose Diana
Publication year - 2008
Publication title -
sociology of health and illness
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 97
eISSN - 1467-9566
pISSN - 0141-9889
DOI - 10.1111/j.1467-9566.2008.01116.x
Subject(s) - pharmacogenomics , ambivalence , tolerability , antidepressant , antidepressant medication , psychiatry , affect (linguistics) , depression (economics) , medicine , mental health , public health , psychology , adverse effect , pharmacology , social psychology , nursing , anxiety , macroeconomics , communication , economics
Whilst antidepressant medications are widely used, they are ineffective for nearly 40 per cent of users and cause numerous adverse drug reactions. The pharmacogenomics of depression attempts to better understand the role of genetic variation in antidepressant metabolism in the hope of improving drug efficacy and tolerability. In this paper we present findings from a series of focus groups with the general public and with mental health service users in four European sites. Results indicate broad support for genome‐based therapies for depression. Findings, however, also show a wide spread of ambivalence regarding the nature and causes of depression, as well as the use of antidepressant medication. We argue that these uncertainties may negatively impact public and user acceptability of the pharmacogenomics of antidepressants.