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The Dantzig Selector in Cox's Proportional Hazards Model
Author(s) -
ANTONIADIS ANESTIS,
FRYZLEWICZ PIOTR,
LETUÉ FRÉDÉRIQUE
Publication year - 2010
Publication title -
scandinavian journal of statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.359
H-Index - 65
eISSN - 1467-9469
pISSN - 0303-6898
DOI - 10.1111/j.1467-9469.2009.00685.x
Subject(s) - lasso (programming language) , mathematics , censoring (clinical trials) , proportional hazards model , statistics , linear regression , regression analysis , feature selection , regression , model selection , multicollinearity , econometrics , artificial intelligence , computer science , world wide web
. The Dantzig selector (DS) is a recent approach of estimation in high‐dimensional linear regression models with a large number of explanatory variables and a relatively small number of observations. As in the least absolute shrinkage and selection operator (LASSO), this approach sets certain regression coefficients exactly to zero, thus performing variable selection. However, such a framework, contrary to the LASSO, has never been used in regression models for survival data with censoring. A key motivation of this article is to study the estimation problem for Cox's proportional hazards (PH) function regression models using a framework that extends the theory, the computational advantages and the optimal asymptotic rate properties of the DS to the class of Cox's PH under appropriate sparsity scenarios. We perform a detailed simulation study to compare our approach with other methods and illustrate it on a well‐known microarray gene expression data set for predicting survival from gene expressions.