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Emotionally controlled decision‐making and a gene variant related to serotonin synthesis in women with borderline personality disorder
Author(s) -
MAUREX LISELOTTE,
ZABOLI GHAZAL,
WIENS STEFAN,
ÅSBERG MARIE,
LEOPARDI ROSARIO,
ÖHMAN ARNE
Publication year - 2009
Publication title -
scandinavian journal of psychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 72
eISSN - 1467-9450
pISSN - 0036-5564
DOI - 10.1111/j.1467-9450.2008.00689.x
Subject(s) - borderline personality disorder , psychology , iowa gambling task , clinical psychology , serotonin , tryptophan hydroxylase , psychiatry , medicine , cognition , serotonergic , receptor
The Iowa Gambling Task (IGT) was used to examine (i) social decision‐making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision‐making and the tryptophan hydroxylase‐1 (TPH‐1) gene, involved in serotonin synthesis. Forty‐two women with BPD and a history of suicide attempts were genotyped, and the frequency of a TPH‐1 haplotype previously uniquely associated with BPD was calculated. The BPD group scored significantly lower than a control group in the IGT. Furthermore, the TPH‐1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. These findings suggest that impaired decision‐making as determined by the IGT is a feature of BPD and may be (i) associated with serotonin dysfunction, and (ii) possibly relevant for suicidal behavior.